\nAre you ready to own the design and optimization of CRISPR screens at Gordian Biotechnology to help us identify therapeutic targets and potential treatments for age-related diseases? We’ve shown that our platform predicts preclinical and clinical physiological responses from in vivo Mosaic screens. You’ll be at the center of a fast-paced team of scientific experts using our platform to run discovery screens for more therapeutic targets than ever before, in the most realistic models of disease!\n\n\nThe Destination:\n\n\nGordian Biotechnology is a therapeutics company whose mission is to cure age-related diseases and ultimately allow people to lead longer, healthier lives. \n\n\nTraditional ex vivo screening methods have failed to produce effective treatments, as age-related diseases have complex causes that include interactions with the aged environment. \n\n\nTo address this problem, Gordian’s platform is the first and only to enable pooled in vivo tests at scale in our proprietary “patient avatars”. We are able to deliver and test hundreds of therapeutics in individual animals, and scale efficacy testing to cover every therapeutic target at the beginning of the drug discovery process (more info on our website). We can choose targets that really impact disease biology, to develop and commercialize therapies for the world’s deadliest diseases, and eventually for the processes of aging itself. \n\n\nThe Journey:\n\n\nOur mission is audacious, and the path will be full of both challenges and excitement. Two things characterize the Gordian experience: 1) We work as a team, with ownership in our own roles and trust in each other. 2) We strive for extraordinary outcomes, and in doing so grow our skills and capability. \n\n\nTeam – Relying on each other begins with transparency. We set clear goals, visibly connecting individuals and teams to our company objectives. This empowers each of us to make autonomous decisions about our work, knowing how they will affect the bigger picture. Our communication happens out in the open. We give and receive feedback from a perspective of helping each other grow, share mistakes, and ask for help. \n\n\nExtraordinary – Every day, we ask ourselves ‘How could this process/outcome be even better?’. Knowing our overall mission, we do what we think helps us make the most progress, without asking for permission. We don’t shy away from big challenges or unknown territory, but find a way to excel. Our colleagues are amazing, both at what they do and as people. They inspire us to keep up, to not let them down, and be inspiring in return. \n\n\nLike any cutting-edge research environment, Gordian doesn't believe in a standard 9 to 5 day. We set ambitious project goals and support each other to meet them, while maintaining the balance individuals need to thrive and achieve excellence. Our team is geared towards helping each other out and maintaining a culture of intellectual and social fun. We like getting things done and keep standing meetings to a minimum. This year, in accordance with our unlimited vacation policy, each member took an average of 4.5 weeks of (offline) vacation, not including major holidays. We unwind with weekly team lunches, and support each others’ projects both experimentally and by ‘pre-mortem’ meetings to discuss possible failure modes and experimental design. \n\n\nIf this environment sounds appealing, help us bring it to life. We are at the beginning of a long journey, and want both your ability and your personality along for the ride. Our culture is a source of great pride; it represents both who we are, and who we wish to be. \n\n\nYou can dive deeper here: https://www.gordian.bio/culture/\n\n\nAbout the Role:\n\n\nYour mission as molecular biologist is to integrate your expert knowledge of CRISPR biology with our in vivo screening platform to develop and improve CRISPR-based screening in Gordian’s therapeutic areas of interest. Your work will use our technology to generate screen hits from potential targets chosen by our in-house disease experts. These hits will then move into preclinical development as potential treatments for these diseases. As the in-house expert of all things CRISPR your work will often take you into areas of science that Gordian has not yet pursued, where you’ll use papers and consultants to quickly get an overview and then design experiments with plenty of controls to simultaneously test multiple biological hypotheses.  Integrating CRISPR screens has many benefits that could make our platform even stronger, enhancing our capabilities, particularly in what targets are available for screening. The impact of your contributions will be profound, driving significant advancements in the therapeutic targets we pursue. \n\n\nAdditionally, you'll design and test DNA constructs with new and improved features to accelerate our screening and validation. You’ll support the molecular biology team goals by managing and executing cloning projects for therapeutic screens and a variety of development projects. Molecular biology is often the bottleneck for initiating new projects, so you’ll need to combine attention to detail with a bias for action and your ability to manage projects effectively and efficiently will be key to your success. \n\n\nGordian does a hefty amount of barcoded multiplexing, and most often you’ll be interpreting biology using sequencing data. Thriving in this environment means keeping a firm grasp of how individual molecules and their copies are moved through our workflows. \n\n\nIn your first month at Gordian, you’ll get fully up to speed with our expression constructs, cloning pipeline and strategies for intervention library cloning. Additionally, you’ll familiarize yourself with Gordian’s current CRISPR screening strategy and plan experiments to better understand our screen data. You’ll also jump in to help the team with cloning. \n\n\nBy two months, you’ll evaluate Gordian’s CRISPR approach and start to implement new proteins/approaches to upgrade our screening capabilities. You’ll strategize on how we analyze CRISPR screens, examining CRISPR screening data in two disease programs and initiate screening in another. And in three months you’ll manage and execute pipeline cloning projects autonomously without need for input from your team and manager. \n\n\nIn six months, you’ll own Gordian’s CRISPR pipeline, from construct design, to in vivo strategy, to managing analysis of transcriptomic and gRNA assignment data. Your work in CRISPR screening will have generated hits in at least one disease area, and made progress with another, in parallel with platform optimization projects. \n\n\nAbout You: \n\n\nYou have a history of successful execution, both in- and outside of your job description. You want a chance to do your best work, immerse yourself and excel, alongside people who will inspire you and whom you’ll be excited to spend your days with. \n\n\nYou truly want to play a key role in an early-stage startup screening new targets for intractable diseases of aging: A fast-paced environment full of both uncertainty and new challenges, demanding relentless resourcefulness. \n\n\nYou have a solid understanding of CRISPR biology, including gRNA design/selection and experimental controls, and experience in either CRISPR screening or CRISPR technology development. \n\n\nYou’re fluent in HiFi and Golden Gate assembly. Bonus points for experience with pooled library cloning.\n\n\nYou design and execute multiple experimental threads to push multiple cloning projects forward at once and are comfortable owning the end to end management of scientific projects. \n\n\nYou’re a crisp communicator, and are able to seamlessly manage collaboration with cross functional partners and teams. \n\n\nBonus points for experience with computational biology, perturbation screening, one or more areas of RNA biology (e.g. transcriptional regulation), molecular quantification assays, cell culture, AAV biology and flow cytometry. \n\n\nThe Details: \n\n\nGordian aims to provide everything you need to thrive. Beyond our community and science, you’ll have enough equity to be a true stakeholder in the company, competitive salary, full health/dental/vision/life insurance, 401k with match, onsite lunch paid for 3 days a week, an onsite gym, whatever vacation you need to be at your peak, remote work flexibility, and access to world-class mentors and advisors to support your professional growth. Our building is in the heart of the biotech capital of South San Francisco.\n\n\n\n\n$115,000 - $140,000 a year\n \n\n#Salary and compensation\n No salary data published by company so we estimated salary based on similar jobs related to Design and Design jobs that are similar:\n\n $70,000 — $100,000/year\n
\n\n#Benefits\n 💰 401(k)\n\n🌎 Distributed team\n\n⏰ Async\n\n🤓 Vision insurance\n\n🦷 Dental insurance\n\n🚑 Medical insurance\n\n🏖 Unlimited vacation\n\n🏖 Paid time off\n\n📆 4 day workweek\n\n💰 401k matching\n\n🏔 Company retreats\n\n🏬 Coworking budget\n\n📚 Learning budget\n\n💪 Free gym membership\n\n🧘 Mental wellness budget\n\n🖥 Home office budget\n\n🥧 Pay in crypto\n\n🥸 Pseudonymous\n\n💰 Profit sharing\n\n💰 Equity compensation\n\n⬜️ No whiteboard interview\n\n👀 No monitoring system\n\n🚫 No politics at work\n\n🎅 We hire old (and young)\n\n
\n\n#Location\nSouth San Francisco, CA

\nAre you ready to play a pivotal role in critical ex vivo validation experiments and research activities to support Gordian’s development of novel drug candidates? We’ve shown that our platform predicts preclinical and clinical physiological responses from in vivo Mosaic screens. You’ll be at the center of a fast-paced team of scientific experts using our platform to run discovery screens for more therapeutic targets than ever before, in the most realistic models of disease!\n\n\nThe Destination:\n\n\nGordian Biotechnology is a therapeutics company whose mission is to cure age-related diseases and ultimately allow people to lead longer, healthier lives. Traditional ex vivo screening methods have failed to produce effective treatments, as age-related diseases have complex causes that include interactions with the aged environment. To address this problem, Gordian’s platform is the first and only to enable pooled in vivo tests at scale in our proprietary “patient avatars”. We are able to deliver and test hundreds of therapeutics in individual animals, and scale efficacy testing to cover every therapeutic target at the beginning of the drug discovery process (more info on our website). We can choose targets that really impact disease biology, to develop and commercialize therapies for the world’s deadliest diseases, and eventually for the processes of aging itself. \n\n\nThe Journey:\n\n\nOur mission is audacious, and the path will be full of both challenges and excitement. Two things characterize the Gordian experience: 1) We work as a team, with ownership in our own roles and trust in each other. 2) We strive for extraordinary outcomes, and in doing so grow our skills and capability. \n\n\nTeam – Relying on each other begins with transparency. We set clear goals, visibly connecting individuals and teams to our company objectives. This empowers each of us to make autonomous decisions about our work, knowing how they will affect the bigger picture. Our communication happens out in the open. We give and receive feedback from a perspective of helping each other grow, share mistakes, and ask for help. \n\n\nExtraordinary – Every day, we ask ourselves ‘How could this process/outcome be even better?’. Knowing our overall mission, we do what we think helps us make the most progress, without asking for permission. We don’t shy away from big challenges or unknown territory, but find a way to excel. Our colleagues are amazing, both at what they do and as people. They inspire us to keep up, to not let them down, and be inspiring in return. \n\n\nLike any cutting-edge research environment, Gordian doesn't believe in a standard 9 to 5 day. We set ambitious project goals and support each other to meet them, while maintaining the balance individuals need to thrive and achieve excellence. Our team is geared towards helping each other out and maintaining a culture of intellectual and social fun. We like getting things done and keep standing meetings to a minimum. This year, in accordance with our unlimited vacation policy, each member took an average of 4.5 weeks of (offline) vacation, not including major holidays. We unwind with weekly team lunches, and support each others’ projects both experimentally and by ‘pre-mortem’ meetings to discuss possible failure modes and experimental design. \n\n\nIf this environment sounds appealing, help us bring it to life. We are at the beginning of a long journey, and want both your ability and your personality along for the ride. Our culture is a source of great pride; it represents both who we are, and who we wish to be. \n\n\nYou can dive deeper here: https://www.gordian.bio/culture/\n\n\nAbout the Role:\n\n\nYour primary mission as Scientist, Complex Ex Vivo Systems is to design and oversee ex vivo experiments to validate our screen results for our HFpEF & IPF disease programs. Specifically, you will architect experimental designs, set up new assays and evaluate the safety, efficacy, and mechanism of action of potential therapeutic targets. \n\n\nYour focus at Gordian is for the validation or elimination of screen hits to happen as early as possible. Gordian is unique in that our in vivo discovery delivers results at a far greater scale than even the largest pharma company. This means that we aren’t dependent on the success of a single target, but can survey the landscape of disease biology for the most promising target (or combination of targets) before moving to therapeutic development. You’ll work closely with our heads of disease biology, managing experimental schedules, and developing assays for in vivo and ex vivo workflows and setting up ex vivo systems to drive forward validation plans for our HFpEF and IPF programs. \n\n\nIn your first month you’ll become familiar with our technology and workflows, developing a strong understanding of the role of the preclinical team at Gordian. You’ll become proficient in our established ex vivo cultures and use your expertise to generate a plan for onboarding one new ex vivo system. Additionally, you’ll work with therapeutic area heads and consultants to generate plan for onboarding human precision cut lung and heart slices\n\n\nBy 2 months, you’ll have set up one complex ex vivo system, owning the entire project, both establishing robust culture methods and optimizing the delivery. You will also start to generate pilot data for a second ex vivo system.\n\n\nAt 3 months, you’ll generate SOPs for one ex vivo system and onboard and train teammates on the method. You’ll have established robust culture methods / delivery for the second ex vivo system. Additionally you’ll have initiated the validation of 10 targets in one ex vivo system as well and by month 4 you’ll have one the same in a second ex vivo system.\n\n\nBy 6 months, you’ll have completed the first round of target validation for two ex vivo systems. \n\n\nAnd You:\n\n\nYou want a chance to do your best work, immerse yourself and excel, alongside people who will inspire you and whom you’ll be excited to spend your days with. \n\n\nYou want to play a key role in an early-stage startup: A fast-paced environment full of both uncertainty and new challenges, demanding relentless resourcefulness.\n\n\nYou are excited to use cutting-edge technology to find the best therapeutic targets, and turn those into drugs. \n\n\nYou have experience in Mammalian cell culture with specific expertise in complex protocols (e.g. iPSC culture, slice cultures, organoids). \n\n\nIdeally you have done long term culture of heart tissues, human iPSCs and ESC culture and  differentiation. \n\n\nYou have experience in human ex vivo culture systems, specifically, with human cardiomyocytes and with human precision cut lung slices.\n\n\nYou’re experienced in RT-QPCR for gene expression in cell and tissue samples as well as Cryosectioning tissues. \n\n\nYou’re experienced with ELISAs, western blot, histology and image analysis (eg: ImageJ) and can effectively interpret the data results. \n\n\nYou have deep experience in assay development (experience with hydroxyproline assays is a plus).\n\n\nYou have experience managing and collaborating on time-sensitive projects, and are comfortable guiding and collaborating across multiple teams to execute experiments at a scale beyond any single person. \n\n\nExperience working in industry and working with Lentiviruses/AAVs are both pluses.\n\n\nThe Details:\n\n\nGordian aims to provide everything you need to thrive. Beyond our community and science, you’ll have enough equity to be a true stakeholder in the company, competitive salary, full health/dental/vision/life insurance, 401k with match, onsite lunch paid for 3 days a week, an onsite gym, whatever vacation you need to be at your peak, remote work flexibility, and access to world-class mentors and advisors to support your professional growth. Our building is in the heart of the biotech capital of South San Francisco.\n\n\n\n\n$115,000 - $150,000 a year\n \n\n#Salary and compensation\n No salary data published by company so we estimated salary based on similar jobs related to Design and Design jobs that are similar:\n\n $95,000 — $125,000/year\n
\n\n#Benefits\n 💰 401(k)\n\n🌎 Distributed team\n\n⏰ Async\n\n🤓 Vision insurance\n\n🦷 Dental insurance\n\n🚑 Medical insurance\n\n🏖 Unlimited vacation\n\n🏖 Paid time off\n\n📆 4 day workweek\n\n💰 401k matching\n\n🏔 Company retreats\n\n🏬 Coworking budget\n\n📚 Learning budget\n\n💪 Free gym membership\n\n🧘 Mental wellness budget\n\n🖥 Home office budget\n\n🥧 Pay in crypto\n\n🥸 Pseudonymous\n\n💰 Profit sharing\n\n💰 Equity compensation\n\n⬜️ No whiteboard interview\n\n👀 No monitoring system\n\n🚫 No politics at work\n\n🎅 We hire old (and young)\n\n
\n\n#Location\nSouth San Francisco, CA

\nScience at Gordian is scaling, and with your help, so will our Chief Scientific Officer (CSO). Gordian is looking for a Scientific Chief of Staff to work as a strategic partner, providing critical support in planning, project management, and communication across our scientific teams that will be essential to drive our science forward. \n\n\nThe Destination:\n\n\nAt Gordian Biotechnology, we are on a mission to cure age-related disease, allowing people to lead longer, healthier lives and wake up every morning, more capable than the day before. \n\n\nAge-related diseases have complex causes that include interactions with the aged environment, and traditional ex vivo screening methods have failed to produce compelling targets or effective treatments. To address this problem, Gordian’s platform enables in vivo Mosaic Screening to deliver and test hundreds of therapeutics in individual animals. We select the most clinically relevant Patient Avatars, whose age, physiology and genomics most closely resembles human patients. Using these and other proprietary tools, we can scale in vivo efficacy testing to more targets than have ever been explored by biopharma,  at the very beginning of the drug discovery process (more info on our website). This lets us develop and commercialize therapies with greater chance of impacting the world’s deadliest diseases, and eventually for the processes of aging itself. \n\n\nThe Journey:Our mission is audacious, and the path will be full of both challenges and excitement. Two things characterize the Gordian experience: 1) We work as a team, with ownership in our own roles and trust in each other. 2) We strive for extraordinary outcomes, and in doing so grow our skills and capability. \n\n\nTeam– Relying on each other begins with transparency. We set clear goals, visibly connecting individuals and teams to our company objectives. This empowers each of us to make autonomous decisions about our work, knowing how they will affect the bigger picture. Our communication happens out in the open. We give and receive feedback from a perspective of helping each other grow, share mistakes, and ask for help. \n\n\nExtraordinary– Every day, we ask ourselves “could this process/outcome be even better?”. Knowing our overall mission, we do what we think helps us make the most progress, without asking for permission. We don’t shy away from big challenges or unknown territory, but find a way to excel. Our colleagues are amazing, both at what they do and as people. They inspire us to keep up, to not let them down, and be inspiring in return. \n\n\nLike any cutting-edge research environment, Gordian doesn't believe in a standard 9 to 5 day. We set ambitious project goals and support each other to meet them, while maintaining the balance individuals need to thrive and achieve excellence. Our team is geared towards helping each other out, an orientation best exemplified through the support we provide for each others’ projects, both experimentally as well as through “pre-mortem” meetings to discuss possible failure modes and experimental design. We like getting things done and keep standing meetings to a minimum. \n\n\nWe like to have social as well as intellectual fun, including through weekly team lunches, monthly company happy hours, and regular social events hosted by Gordian for the broader community. We also encourage our colleagues to unwind; this year, in accordance with our unlimited vacation policy, each member took an average of 4.5 weeks of (offline) vacation, not including major holidays. \n\n\nIf this environment sounds appealing, come experience it with us. We are at the beginning of a long journey, and want both your ability and your personality along for the ride. Our culture is a source of great pride; it represents both who we are, and who we wish to be. \n\n\nYou can dive deeper here: https://www.gordian.bio/culture/. \n\n\nThe Role:\n\n\nYour primary mission as Scientific Chief of Staff is to provide tactical support to our CSO, working closely with him to absorb Gordian’s strategy  and own various initiatives across the company to achieve both our short-term and long-term goals. You will be at the center of our organization, staying updated on scientific projects and resource constraints as well as engaging in strategic discussions. You’ll help the CSO with operational tasks, keep track of the balls they are holding, and stay on top of company deadlines and strategic dates. \n\n\nYou’ll spend a significant amount of your time learning from our CSO to gain key insights into our mission and vision, critical strategic and organizational initiatives and becoming well versed in our culture. This will give you the insight needed to think strategically about areas of improvement in both scientific and operational workflows and partner with our scientific teams to coordinate cross matrix work. \n\n\nInternally, you’ll spend time closely collaborating with our CSO to flesh out and take on projects aimed at broadly improving strategy, collaboration, and culture at Gordian. Your passion to immerse yourself in the challenges of a fast growing startup will fuel you to proactively take on sometimes ambiguous projects and gather information from multiple teams and stakeholders to ensure the successful execution of these projects. \n\n\nAs you grow in the role you’ll have the opportunity to start managing external relationships, communicating with key partners and scientific advisors to enable collaborations and goodwill. You’ll think about and execute ways to build our external brand, through events, social media, and other communications. \n\n\nIn your first month you will become familiar with our technology and disease programs through our training materials, training by the CSO, and self-study, to the point where you can sit in the CSO’s place in meetings and effectively summarize key points. You’ll take careful notes throughout the onboarding process in preparation for producing updated onboarding documentation for new employees. Additionally, you’ll take over a project to manage Gordian’s Small Business Innovation Research grant and will coordinate experiments across multiple teams to ensure they are progressing as planned. \n\n\nIn two months, you’ll have developed a strong understanding of Gordian’s strategy for 2024 and are proactively assisting the CSO in staying on ongoing projects and deadlines, ensuring we stay on track with timelines. You’ll finalize onboarding materials to be rolled out to future new hires. \n\n\nBy four months you will have fully immersed yourself in Gordian’s culture and have a good understanding of our strategic path forward and what needs to happen to get us there.  You have established a strong partnership with the CSO and are comfortable engaging in thoughtful discourse with them including disagreeing and pushing back as you think it relates to effectively executing our companywide plans and goals. As part of this, you’ll have completed an overhaul of how Gordian visualizes goals and deadlines including the dependencies between them and you’ll roll this out to the larger team so there is a unified understanding of what needs to happen. \n\n\nAnd You:\n\n\nYou want a chance to do your best work, immerse yourself and excel, alongside people who will inspire you and whom you’ll be excited to spend your days with. \n\n\nYou want to play a key role in an early-stage startup: A fast-paced environment full of both uncertainty and new challenges, demanding relentless resourcefulness. \n\n\nYou have a knack for absorbing both ideas and preferences, to rapidly develop a sense of how our CSO would act in a given situation. \n\n\nYou have good judgment, good taste, and drive efforts to completion. You also show a high level of integrity, maturity and conscientiousness  in the work you do. \n\n\nYou have strong organizational skills, with the ability to manage multiple projects, tasks and timelines. \n\n\nYou are comfortable guiding and collaborating across multiple teams. You have excellent communication skills, both written and visual. Additionally you have a high standard of work and commitment to quality. \n\n\nYou love science, and are committed to ensuring that treatments reach patients in need, but feel that your skills are best suited outside of the lab. You enjoy the “strategy” of science as much as (or maybe more than) the doing of science. \n\n\nHaving a moderate understanding or previous work history focused on molecular biology, physiology, and genomics, will be helpful.\n\n\nThe Details:\n\n\nGordian aims to provide everything you need to thrive. Beyond our community and science, you’ll have enough equity to be a true stakeholder in the company, competitive salary, full health/dental/vision/life insurance, 401k with match, onsite lunch paid for 3 days a week, an onsite gym, whatever vacation you need to be at your peak, remote work flexibility, and access to world-class mentors and advisors to support your professional growth. Our building is in the heart of the biotech capital of South San Francisco.\n\n\n\n\n$115,000 - $160,000 a year\n \n\n#Salary and compensation\n No salary data published by company so we estimated salary based on similar jobs related to Non Tech and Non Tech jobs that are similar:\n\n $50,000 — $75,000/year\n
\n\n#Benefits\n 💰 401(k)\n\n🌎 Distributed team\n\n⏰ Async\n\n🤓 Vision insurance\n\n🦷 Dental insurance\n\n🚑 Medical insurance\n\n🏖 Unlimited vacation\n\n🏖 Paid time off\n\n📆 4 day workweek\n\n💰 401k matching\n\n🏔 Company retreats\n\n🏬 Coworking budget\n\n📚 Learning budget\n\n💪 Free gym membership\n\n🧘 Mental wellness budget\n\n🖥 Home office budget\n\n🥧 Pay in crypto\n\n🥸 Pseudonymous\n\n💰 Profit sharing\n\n💰 Equity compensation\n\n⬜️ No whiteboard interview\n\n👀 No monitoring system\n\n🚫 No politics at work\n\n🎅 We hire old (and young)\n\n
\n\n#Location\nSouth San Francisco, CA

\nAre you ready to take ownership of Gordian’s unique in vivo screening platform, and evolve it into an even more powerful tool for predicting patient outcomes? You will be managing an interdisciplinary team of experts with a focus on operational excellence in executing screens, while finding ways for in vivo answers to improve both early and later stages of drug development for complex diseases.  \n\n\nThe Destination:\n\n\nGordian Biotechnology is a therapeutics company whose mission is to cure age-related diseases and ultimately allow people to lead longer, healthier lives. \n\n\nTraditional ex vivo screening methods have failed to produce effective treatments, as age-related diseases have complex causes that include interactions with the aged environment. \n\n\nTo address this problem, Gordian’s platform is the first and only to enable pooled in vivo tests at scale in our proprietary “patient avatars”. We are able to deliver and test hundreds of therapeutics in individual animals, and scale efficacy testing to cover every therapeutic target at the beginning of the drug discovery process (more info on our website). We can choose targets that really impact disease biology, to develop and commercialize therapies for the world’s deadliest diseases, and eventually for the processes of aging itself. \n\n\nThe Journey:\n\n\nOur mission is audacious, and the path will be full of both challenges and excitement. Two things characterize the Gordian experience: 1) We work as a team, with ownership in our own roles and trust in each other. 2) We strive for extraordinary outcomes, and in doing so grow our skills and capability. \n\n\nTeam – Relying on each other begins with transparency. We set clear goals, visibly connecting individuals and teams to our company objectives. This empowers each of us to make autonomous decisions about our work, knowing how they will affect the bigger picture. Our communication happens out in the open. We give and receive feedback from a perspective of helping each other grow, share mistakes, and ask for help. \n\n\nExtraordinary – Every day, we ask ourselves ‘How could this process/outcome be even better?’. Knowing our overall mission, we do what we think helps us make the most progress, without asking for permission. We don’t shy away from big challenges or unknown territory, but find a way to excel. Our colleagues are amazing, both at what they do and as people. They inspire us to keep up, to not let them down, and be inspiring in return. \n\n\nLike any cutting-edge research environment, Gordian doesn't believe in a standard 9 to 5 day. We set ambitious project goals and support each other to meet them, while maintaining the balance individuals need to thrive and achieve excellence. Our team is geared towards helping each other out and maintaining a culture of intellectual and social fun. We like getting things done and keep standing meetings to a minimum. This year, in accordance with our unlimited vacation policy, each member took an average of 4.5 weeks of (offline) vacation, not including major holidays. We unwind with weekly team lunches, and support each others’ projects both experimentally and by ‘pre-mortem’ meetings to discuss possible failure modes and experimental design. \n\n\nIf this environment sounds appealing, help us bring it to life. We are at the beginning of a long journey, and want both your ability and your personality along for the ride. Our culture is a source of great pride; it represents both who we are, and who we wish to be. \n\n\nYou can dive deeper here. \n\n\nAbout the Role:\n\n\nYour mission as VP of Platform is to own the application and evolution of Gordian’s mosaic screening platform, leading the team producing transcriptomic data on potential therapeutic targets across MASH, HFpEF, IPF, & Osteoarthritis from our pooled in vivo screens. \n\n\nYour team has been recruited for their expertise and enthusiasm and are already firing on all cylinders. They are always executing multiple overlapping projects demanding a high level of coordination and logistical planning. You must ensure continued operational excellence and efficiency of the team, helping organize and prioritize while balancing execution towards company goals with continuous improvement of processes and exploration of innovative ideas from the team. An important part of your job is to determine which efforts and initiatives are critical to achieving our next milestones, and provide structure for achieving these. \n\n\nMost of your team’s work results in high-dimensional genomics data that requires analysis by our computational team to interpret. You will use your experience and comprehension, in collaboration with our head of data, to ensure that the platform and data teams communicate seamlessly and operate in lockstep to produce and make accessible the data that fuels our company. Under your leadership the team will be integrated both with their collaborators across the company, and have a clear sense of how their work ties to company strategy. You will digest ambiguity and imperfect information to provide your team with clear directions and conditions for having their work contribute to us reaching our shared goals. \n\n\nOur technology is being used to run large Mosaic screens and discover new therapeutic targets, but can be applied to provide scaled in vivo answers to many other questions.  We will count on you to guide evolution of the platform into providing answers that help drug development and decisions about clinical strategy.  This will transform the value of our platform in improving predictive validity in drug development, and cement the promise of our in vivo approach to the world. \n\n\nIn your first month, you’ll build rapport with the Platform team earning their trust and understanding the work of each member as well as the know-how we’ve developed for in vivo screening. You’ll provide guidance and clarity for the team’s work, while identifying  at least one area of strategic improvement for the team or technology and mapping out the right path to accomplish it. \n\n\nBy three months, the platform team is operating smoothly at a scale that is producing 5-10 hits per month, interfacing  effectively with other teams (i.e. computational biology, disease leads) without CSO involvement. Additionally, you will have led the adaptation of our platform to produce data supporting at least one aspect of drug development (outside of target identification) and will have guided the implementation of one or more new methods to improve our cost or time per interpretable result by 20% or more. \n\n\nAbout you:\n\n\nYou have a history of successful execution, both in- and outside of your job description. \n\n\nYou want a chance to do your best work, immerse yourself and excel, alongside people who will inspire you and whom you’ll be excited to spend your days with. \n\n\nYou truly want to play a key role in an early-stage startup screening new targets for intractable diseases of aging: A fast-paced environment full of both uncertainty and new challenges, demanding relentless resourcefulness. \n\n\nYou have experience with strategic technology leadership in biotech (preferably in drug discovery) and setting the direction for an established but evolving platform or suite of technologies. \n\n\nYou have worked at the intersection of molecules and computation and speak computational biology as a first or second language. You’re familiar with genomic datasets and their challenges. \n\n\nYou have’ve got experience managing a collaborative team in a fast-paced environment, and your team members will tell us that you brought out the best in them. You’re a crisp communicator, and are able to seamlessly manage collaboration with cross functional partners and teams. \n\n\nYou are excited to use cutting edge technology to find the best therapeutic targets, and turn those into drugs. You are familiar with pooled screening, barcoding, and the associated pitfalls and challenges, and ideally also with in vivo gene delivery and experimentation. \n\n\nThe Details:\n\n\nGordian aims to provide everything you need to thrive. Beyond our community and science, you’ll have enough equity to be a true stakeholder in the company, competitive salary, full health/dental/vision/life insurance, 401k with match, onsite lunch paid for 3 days a week, an onsite gym, whatever vacation you need to be at your peak, remote work flexibility, and access to world-class mentors and advisors to support your professional growth. Our building is in the heart of the biotech capital of South San Francisco.\n\n\n\n\n$220,000 - $310,000 a year\n \n\n#Salary and compensation\n No salary data published by company so we estimated salary based on similar jobs related to Testing and Non Tech jobs that are similar:\n\n $45,000 — $76,250/year\n
\n\n#Benefits\n 💰 401(k)\n\n🌎 Distributed team\n\n⏰ Async\n\n🤓 Vision insurance\n\n🦷 Dental insurance\n\n🚑 Medical insurance\n\n🏖 Unlimited vacation\n\n🏖 Paid time off\n\n📆 4 day workweek\n\n💰 401k matching\n\n🏔 Company retreats\n\n🏬 Coworking budget\n\n📚 Learning budget\n\n💪 Free gym membership\n\n🧘 Mental wellness budget\n\n🖥 Home office budget\n\n🥧 Pay in crypto\n\n🥸 Pseudonymous\n\n💰 Profit sharing\n\n💰 Equity compensation\n\n⬜️ No whiteboard interview\n\n👀 No monitoring system\n\n🚫 No politics at work\n\n🎅 We hire old (and young)\n\n
\n\n#Location\nSouth San Francisco, CA

\nScience at Gordian is scaling, and with your help, so will our Chief Scientific Officer (CSO). Gordian is looking for a Scientific Chief of Staff to work as a strategic partner, providing critical support in planning, communication, and decision-making across our scientific teams that will be essential to drive our science forward.\n\n\nThe Destination:\n\n\nAt Gordian Biotechnology, we are on a mission to cure age-related disease, allowing people to lead longer, healthier lives and wake up every morning, more capable than the day before.\n\n\nAge-related diseases have complex causes that include interactions with the aged environment, and traditional ex vivo screening methods have failed to produce compelling targets or effective treatments. To address this problem, Gordian’s platform enables in vivo Mosaic Screening to deliver and test hundreds of therapeutics in individual animals. We select the most clinically relevant Patient Avatars, whose age, physiology and genomics most closely resembles human patients. Using these and other proprietary tools, we can scale in vivo efficacy testing to more targets than have ever been explored by biopharma,  at the very beginning of the drug discovery process (more info on our website). This lets us develop and commercialize therapies with greater chance of impacting the world’s deadliest diseases, and eventually for the processes of aging itself. \n\n\nThe Journey:\n\n\nOur mission is audacious, and the path will be full of both challenges and excitement. Two things characterize the Gordian experience: 1) We work as a team, with ownership in our own roles and trust in each other. 2) We strive for extraordinary outcomes, and in doing so grow our skills and capability. \n\n\nTeam – Relying on each other begins with transparency. We set clear goals, visibly connecting individuals and teams to our company objectives. This empowers each of us to make autonomous decisions about our work, knowing how they will affect the bigger picture. Our communication happens out in the open. We give and receive feedback from a perspective of helping each other grow, share mistakes, and ask for help. \n\n\nExtraordinary – Every day, we ask ourselves “could this process/outcome be even better?”. Knowing our overall mission, we do what we think helps us make the most progress, without asking for permission. We don’t shy away from big challenges or unknown territory, but find a way to excel. Our colleagues are amazing, both at what they do and as people. They inspire us to keep up, to not let them down, and be inspiring in return. \n\n\nLike any cutting-edge research environment, Gordian doesn't believe in a standard 9 to 5 day. We set ambitious project goals and support each other to meet them, while maintaining the balance individuals need to thrive and achieve excellence. Our team is geared towards helping each other out, an orientation best exemplified through the support we provide for each others’ projects, both experimentally as well as through “pre-mortem” meetings to discuss possible failure modes and experimental design. We like getting things done and keep standing meetings to a minimum. \n\n\nWe like to have social as well as intellectual fun, including through weekly team lunches, monthly company happy hours, and regular social events hosted by Gordian for the broader community. We also encourage our colleagues to unwind; this year, in accordance with our unlimited vacation policy, each member took an average of 2.5 weeks of (offline) vacation, not including major holidays.\n\n\nIf this environment sounds appealing, come experience it with us. We are at the beginning of a long journey, and want both your ability and your personality along for the ride. Our culture is a source of great pride; it represents both who we are, and who we wish to be. You can dive deeper here: https://www.gordian.bio/s/Gordian-values.pdf. \n\n\nThe Role:\n\n\nYour primary mission as Scientific Chief of Staff is to be an extension of our CSO, working closely with him to absorb and implement strategic skills and initiatives across the company. \n\n\nYou will be an integral part of our organization, participating in sync meetings, engaging in strategic discussions, and gradually standing in for the CSO in various interactions, relieving them of operational tasks to focus on research and development. \n\n\nYou'll spend a significant amount of your time learning from our CSO to gain key insights into our mission and vision, critical strategic and organizational initiatives and becoming well versed in our culture. This will give you the insight needed to partner with our scientific teams to provide guidance on prioritization, cross-company impact, and other factors required to align our work across teams. \n\n\nYou'll also have a significant role in managing external relationships, communicating with key partners and scientific advisors to enable collaborations and goodwill. You’ll think about and execute ways to build our external brand, through events, social media, and other communications. \n\n\nInternally, you’ll  spend time closely collaborating with our CSO to flesh out and take on projects aimed at broadly improving strategy, collaboration, and culture at Gordian. You’ll combine organization and enthusiasm to successfully jump into challenging and sometimes ambiguous projects, while also removing operational tasks from our CSO and staying on top of company deadlines and strategic dates. \n\n\nIn your first month you will become familiar with our technology and disease programs assisting our CSO in coordinating matrix work. You’ll create a manual capturing scientific, cultural, and organizational onboarding for new employees. Additionally you’ll take over a project to manage Gordian’s Small Business Innovation Research grant work ensuring the necessary meetings are scheduled and experiments are progressing as planned. \n\n\nIn two months, you’ll have developed a strong understanding of Gordian’s strategy for 2024 and are assisting the CSO in overseeing key projects in partnership with our disease leads and functional leads. You’ll have successfully completed one project that is a key rock or blocker for Gordian (examples could include developing a project management handbook, developing a company-visible version of goals/metrics for 2024, etc.)\n\n\nBy three months you will have fully immersed yourself in Gordian’s culture and can take over the majority of preparations and management for a critical brand launch. You have also proven your ability to quickly adapt and handle unexpected responsibilities and challenges that arise, and are seizing unexpected opportunities to support Gordian’s mission.\n\n\nAnd You :\n\n\nYou want a chance to do your best work, immerse yourself and excel, alongside people who will inspire you and whom you’ll be excited to spend your days with. \n\n\nYou want to play a key role in an early-stage startup: A fast-paced environment full of both uncertainty and new challenges, demanding relentless resourcefulness. \n\n\nYou love science, and are committed to ensuring that treatments reach patients in need, but feel that your skills are best suited outside of the lab. You enjoy the “strategy” of science as much as (or maybe more than) the doing of science. \n\n\nYou have a knack for absorbing both ideas and preferences, to rapidly develop a sense of how our CSO would act in a given situation. You have good judgment, good taste, and drive efforts to completion.\n\n\nYou have strong organizational skills, with the ability to manage multiple projects, tasks and timelines. You are comfortable guiding and collaborating across multiple teams.\n\n\nYou have excellent communication skills, both written and visual. Additionally you have a high standard of work and commitment to quality. \n\n\nHaving a moderate understanding or previous work history focused on molecular biology, physiology, and genomics, will be extremely helpful. \n\n\nThe Details:\n\n\nGordian aims to provide everything you need to thrive. Beyond our community and science, you’ll have enough equity to be a true stakeholder in the company, competitive salary, full health/dental/vision/life insurance, 401k with match, onsite lunch paid for 3 days a week, an onsite gym, whatever vacation you need to be at your peak, remote work flexibility, and access to world-class mentors and advisors to support your professional growth. Our building is in the heart of the biotech capital of South San Francisco.\n\n\n\n\n$125,000 - $160,000 a year\n \n\n#Salary and compensation\n No salary data published by company so we estimated salary based on similar jobs related to Testing and Non Tech jobs that are similar:\n\n $40,000 — $62,500/year\n
\n\n#Benefits\n 💰 401(k)\n\n🌎 Distributed team\n\n⏰ Async\n\n🤓 Vision insurance\n\n🦷 Dental insurance\n\n🚑 Medical insurance\n\n🏖 Unlimited vacation\n\n🏖 Paid time off\n\n📆 4 day workweek\n\n💰 401k matching\n\n🏔 Company retreats\n\n🏬 Coworking budget\n\n📚 Learning budget\n\n💪 Free gym membership\n\n🧘 Mental wellness budget\n\n🖥 Home office budget\n\n🥧 Pay in crypto\n\n🥸 Pseudonymous\n\n💰 Profit sharing\n\n💰 Equity compensation\n\n⬜️ No whiteboard interview\n\n👀 No monitoring system\n\n🚫 No politics at work\n\n🎅 We hire old (and young)\n\n
\n\n#Location\nSouth San Francisco, CA

\nAre you ready to play a pivotal role in critical validation and development experiments and research activities to support Gordian’s path to clinical trials for novel drug candidates? \n\n\nWe’ve shown that our platform predicts preclinical and clinical physiological responses from in vivo Mosaic screens. You’ll be at the center of a fast-paced team of scientific experts using our platform to run discovery screens for more therapeutic targets than ever before, in the most realistic models of disease!\n\n\nThe Destination:\n\n\nAt Gordian Biotechnology, we are on a mission to cure age-related disease, allowing people to lead longer, healthier lives and wake up every morning, more capable than the day before. \n\n\nAge-related diseases have complex causes that include interactions with the aged environment, and traditional ex vivo screening methods have failed to produce compelling targets or effective treatments. To address this problem, Gordian’s platform enables in vivo Mosaic Screening to deliver and test hundreds of therapeutics in individual animals. We select the most clinically relevant Patient Avatars, whose age, physiology and genomics most closely resembles human patients. Using these and other proprietary tools, we can scale in vivo efficacy testing to more targets than have ever been explored by biopharma,  at the very beginning of the drug discovery process (more info on our website). This lets us develop and commercialize therapies with greater chance of impacting the world’s deadliest diseases, and eventually for the processes of aging itself. \n\n\nThe Journey:\n\n\nOur mission is audacious, and the path will be full of both challenges and excitement. Two things characterize the Gordian experience: 1) We work as a team, with ownership in our own roles and trust in each other. 2) We strive for extraordinary outcomes, and in doing so grow our skills and capability. \n\n\nTeam – Relying on each other begins with transparency. We set clear goals, visibly connecting individuals and teams to our company objectives. This empowers each of us to make autonomous decisions about our work, knowing how they will affect the bigger picture. Our communication happens out in the open. We give and receive feedback from a perspective of helping each other grow, share mistakes, and ask for help. \n\n\nExtraordinary – Every day, we ask ourselves “could this process/outcome be even better?”. Knowing our overall mission, we do what we think helps us make the most progress, without asking for permission. We don’t shy away from big challenges or unknown territory, but find a way to excel. Our colleagues are amazing, both at what they do and as people. They inspire us to keep up, to not let them down, and be inspiring in return. \n\n\nLike any cutting-edge research environment, Gordian doesn't believe in a standard 9 to 5 day. We set ambitious project goals and support each other to meet them, while maintaining the balance individuals need to thrive and achieve excellence. Our team is geared towards helping each other out, an orientation best exemplified through the support we provide for each others’ projects, both experimentally as well as through “pre-mortem” meetings to discuss possible failure modes and experimental design. We like getting things done and keep standing meetings to a minimum. \n\n\nWe like to have social as well as intellectual fun, including through weekly team lunches, monthly company happy hours, and regular social events hosted by Gordian for the broader community. We also encourage our colleagues to unwind; this year, in accordance with our unlimited vacation policy, each member took an average of 2.5 weeks of (offline) vacation, not including major holidays. \n\n\nIf this environment sounds appealing, come experience it with us. We are at the beginning of a long journey, and want both your ability and your personality along for the ride. Our culture is a source of great pride; it represents both who we are, and who we wish to be. \n\n\nYou can dive deeper here: https://www.gordian.bio/s/Gordian-values.pdf. \n\n\nThe Role:\n\n\nYour primary mission as Senior Scientist, Preclinical Development is to design and oversee experiments for validation (proof of concept) and development (IND enablement), and lead our Preclinical team’s operations to maximize scientific rigor in our drug discovery process. Specifically, you will architect experimental designs, set up new assays, disease models and gene delivery, as well as design efficacy, biodistribution and toxicity experiments to evaluate the safety and mechanism of action of potential therapeutic targets. \n\n\nYour focus at Gordian is for the validation or elimination of screen hits to happen as early as possible. Gordian is unique in that our in vivo discovery delivers results at a far greater scale than even the largest pharma company. This means that we aren’t dependent on the success of a single target, and will allow you to survey the landscape of disease biology for the most promising target (or combination of targets) before leading their development towards clinical trials. You’ll work closely with our functional teams, managing experimental schedules, and setting up in vivo systems to drive forward validation and development plans. You’ll have a significant leadership role in our Preclinical function, developing processes for your team that both minimize inefficiencies and empowers people to do their best work. \n\n\nAs an in vivo expert, you're able to provide meaningful guidance and mentorship, leading projects and providing support to your team as challenges arise.\n\n\nIn your first month you’ll become familiar with our technology and workflows, developing a strong understanding of the role of the preclinical team at Gordian, and you’ll use your expertise to quickly become familiar with our in vivo techniques. \n\n\nBy 3 months, you’ll have a strong understanding of all ongoing validation plans, and will already be thinking critically about how we can be doing them better, working closely with our team and key stakeholders to identify assays for development of each indication. You’ll contribute to the design and execution of validation experiments for two indications and will be fully onboarded to manage at least one direct report. \n\n\nBy 6 months you’ll have established efficient processes to significantly improve in vivo and assay work and will have optimized assays for four indications. You’ll be fully ramped up in your management role leading 4-5 reports on the Preclinical team. You’ll have started working closely with our disease area leads, our advisory board members and our executive team to formulate a therapeutic development plan.\n\n\nAnd You: \n\n\nYou want a chance to do your best work, immerse yourself and excel, alongside people who will inspire you and whom you’ll be excited to spend your days with. \n\n\nYou want to play a key role in an early-stage startup: A fast-paced environment full of both uncertainty and new challenges, demanding relentless resourcefulness. \n\n\nYou are excited to use cutting-edge technology to find the best therapeutic targets, and turn those into drugs. \n\n\nYou have >8 years hands-on in vivo experience (e.g. surgeries, dosing, behavior).\n\n\nYou have >4 years of industry experience in efficacy, biodistribution and toxicology studies (small molecules or biologics/gene therapies). \n\n\nYou’re an experienced people leader and have managed a team of wet lab researchers. \n\n\nYou have experience with histology and diverse assay types as well a strong data analysis skill set. \n\n\nYou have a history of managing and collaborating on time-sensitive projects, and are comfortable guiding and collaborating across multiple teams to execute experiments at a scale beyond any single person.\n\n\nExperience with pharmacokinetics/pharmacodynamics, a background designing and executing IND enablement experiments, and experience working with Lentiviruses/AAVs are all pluses. \n\n\nThe Details:\n\n\nGordian aims to provide everything you need to thrive. Beyond our community and science, you’ll have enough equity to be a true stakeholder in the company, competitive salary, full health/dental/vision/life insurance, 401k with match, onsite lunch paid for 3 days a week, an onsite gym, whatever vacation you need to be at your peak, remote work flexibility, and access to world-class mentors and advisors to support your professional growth. Our building is in the heart of the biotech capital of South San Francisco.\n\n\n\n\n$125,000 - $160,000 a year\n \n\n#Salary and compensation\n No salary data published by company so we estimated salary based on similar jobs related to Design, Testing and Senior jobs that are similar:\n\n $50,000 — $70,000/year\n
\n\n#Benefits\n 💰 401(k)\n\n🌎 Distributed team\n\n⏰ Async\n\n🤓 Vision insurance\n\n🦷 Dental insurance\n\n🚑 Medical insurance\n\n🏖 Unlimited vacation\n\n🏖 Paid time off\n\n📆 4 day workweek\n\n💰 401k matching\n\n🏔 Company retreats\n\n🏬 Coworking budget\n\n📚 Learning budget\n\n💪 Free gym membership\n\n🧘 Mental wellness budget\n\n🖥 Home office budget\n\n🥧 Pay in crypto\n\n🥸 Pseudonymous\n\n💰 Profit sharing\n\n💰 Equity compensation\n\n⬜️ No whiteboard interview\n\n👀 No monitoring system\n\n🚫 No politics at work\n\n🎅 We hire old (and young)\n\n
\n\n#Location\nSan Francisco